Business in Agartala varies from small handloom industries to big gas-based projects. Being close to Assam, tea forms another major part of the city's commercial activities. Handicrafts, rubber, tourism and food processing industries are also flourishing here.

Bamboo and cane hold an important place in the lives of the people of Agartala. Those involved in handicraft, mould and weave them into various shapes to create ornaments, containers and toys. These artefacts are prepared with such intricate design and perfection that they are famous all-over India and abroad. To improve the quality of the products, the All India Handicraft Board has set up a research unit in the city.

Agartala is blessed with an abundance of natural resources including natural gas. Numerous gas-based industries have come up since high quality gas is available at much cheaper rates in this part of the country. The state government has also encouraged several projects that will enhance and put to use such resources that can be a great source for energy-intensive projects.

Seri-culture industry is an age-old sector that is progressing fast in Agartala.